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Erectile Function: Endothelium, PDE5, and cGMP

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Erectile Function: Endothelium, PDE5, and cGMP
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The physiological mechanisms behind erections, focusing on the roles of the endothelium, cyclic guanosine monophosphate (cGMP), and phosphodiesterase type 5 (PDE5). It details how nitric oxide, released by the endothelium, activates cGMP to relax penile arteries, enabling erections, while PDE5 breaks down cGMP to end them. Erectile dysfunction arises from impaired endothelial function or excessive PDE5 activity, which can be addressed through lifestyle changes or PDE5 inhibitors. The text emphasizes the importance of vascular health and a healthy lifestyle for maintaining sexual health.

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